Nasal spray based on nasty intestinal bug to stop the flu

Nasal spray based on nasty intestinal bug to stop the flu










A nasal spray vaccine containing an insect that causes food poisoning may be more effective than injections in preventing the flu.

The spray contains a flu vaccine mixed with the bacteria Escherichia coli (E. coli), which can cause severe stomach cramps, diarrhea and vomiting.

The addition of E.coli helps trigger a stronger immune system response to the virus than existing influenza vaccines. Using this spray directly into the nasal lining can prime the immune system to block the virus for up to six months, according to a study by researchers at the National Taiwan University Hospital.

By working directly on the nose and throat, the spray encourages the production of more antibodies to the point where the flu virus typically invades the human body, they said. The results of the trial, involving 350 patients, show the vaccine to be safe and effective, triggering a stronger immune response than a conventional influenza vaccine.

The spray contains a flu vaccine mixed with the bacteria Escherichia coli (E. coli), which can cause severe stomach cramps, diarrhea and vomiting. Addition of E.coli helps trigger stronger immune system response to virus than existing influenza vaccines

Influenza causes relatively mild illness in most people, but it can reach the lower respiratory system, leading to fatal pneumonia in severe cases, especially among vulnerable groups, including people over 65 and those with disabilities. underlying health problems. More than 20,000 in the UK died from the flu in 2017-18.

It is estimated that influenza vaccines prevented between 15 and 52% of influenza cases between 2015 and 2020. But their effectiveness varies.

Influenza vaccines – usually made with inactivated viruses – trigger the production of antibodies.

The nasal spray versions, which avoid needles, contain live viruses that are weakened so as not to cause disease while generating a stronger immune response (including more sophisticated T cells and B cells) – and, in the cases of respiratory infections, can be delivered directly to where the viruses replicate.

But nasal sprays are not always effective, especially because it is more difficult to tell how much vaccine has been given.

It is estimated that influenza vaccines prevented between 15 and 52% of influenza cases between 2015 and 2020. But their effectiveness varies.  Flu vaccines - usually made with inactivated viruses - trigger the production of antibodies

It is estimated that influenza vaccines prevented between 15 and 52% of influenza cases between 2015 and 2020. But their effectiveness varies. Flu vaccines – usually made with inactivated viruses – trigger the production of antibodies

The spray, developed by Taiwanese company Advagene Biopharma, contains an influenza vaccine wrapped in detoxified (harmless) E.coli. The idea is that by mounting a response to the bacteria, the body also creates more antibodies against the influenza virus.

The research, reported in the journal Vaccine, showed that those who used the spray had higher amounts of antibodies in their blood than those who received a control vaccine injection.

Greg Towers, professor of molecular virology at University College London, said: “All vaccines contain a component called an adjuvant to activate the immune system. Here, the adjuvant is derived from E. coli – a great immune enhancer – so it works well.

“A nasal response should also be more effective if it is driven by the right antigen in the right place – the nose and the airways – than when it is given in the arm,” he adds, explaining that “the nose has evolved to become a protective barrier and, as such, the immunity that can be induced here is particularly effective ”.

n Cleaning surfaces with a soap containing pine resin could help remove particles from influenza and other viruses, reports the journal Microbiology Spectrum.

Scientists have found that soap made from a solid form of resin can inactivate the influenza virus, reducing its ability to transmit infection 100,000 times.

Researchers, from Queen’s University in Belfast, say that at a concentration of 2.5%, soap can break down the fatty (lipid) envelope that surrounds viruses such as the flu.

Try that

Cheeses are crisp, cube-shaped snacks made only from baked cheese (there is a range of cheeses available). Each 20g sachet contains 8g of protein (about one-fifth of a woman’s daily requirement).

Costs £ 1.20 per 20g bag, ocado.com

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